2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

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Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17358R
    Loteprednol Etabonate (Standard)
    		Agonist
    Loteprednol Etabonate (Standard) is the analytical standard of Loteprednol Etabonate. This product is intended for research and analytical applications. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.
    Loteprednol Etabonate (Standard)
  • HY-B0415R
    Fluocinolone (Acetonide) (Standard)
    		Agonist
    Fluocinolone (Acetonide) (Standard) is the analytical standard of Fluocinolone (Acetonide). This product is intended for research and analytical applications. Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015).
    Fluocinolone (Acetonide) (Standard)
  • HY-U00043
    Triamcinolone Benetonide
    		Modulator
    Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
    Triamcinolone Benetonide
  • HY-13571R
    Betamethasone dipropionate (Standard)
    		Modulator
    Betamethasone dipropionate (Standard) is the analytical standard of Betamethasone dipropionate. This product is intended for research and analytical applications. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
    Betamethasone dipropionate (Standard)
  • HY-B1829R
    Dexamethasone phosphate (Standard)
    		Agonist
    Dexamethasone phosphate (Standard) is the analytical standard of Dexamethasone phosphate. This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, Dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate disodium-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research.
    Dexamethasone phosphate (Standard)
  • HY-W701984
    11β-Hydroxyetiocholanolone
    		Control
    11β-Hydroxyetiocholanolone is a metabolite of Hydrocortisone (HY-N0583). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    11β-Hydroxyetiocholanolone
  • HY-171460
    Win 45164
    		Inhibitor
    Win 45164 is an orally active glucocorticoid receptor (Glucocorticoid Receptor) ligand with the activity of inhibiting the pituitary - adrenal axis. It can promote liver glycogen deposition and thymus involution in adrenalectomized male rats. Meanwhile, Win 45164 has anti - inflammatory effects. It can be used in the research of inflammatory and neurological diseases.
    Win 45164
  • HY-B1265R
    Hydrocortisone 17-valerate (Standard)
    Hydrocortisone 17-valerate (Standard) is the analytical standard of Hydrocortisone 17-valerate. This product is intended for research and analytical applications. Hydrocortisone 17-valerate (Cortisol 17-valerate) is a thiazolidine compound.
    Hydrocortisone 17-valerate (Standard)
  • HY-107961R
    Diflorasone diacetate (Standard)
    Diflorasone diacetate (Standard) is the analytical standard of Diflorasone diacetate. This product is intended for research and analytical applications. Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses.
    Diflorasone diacetate (Standard)
  • HY-135061
    20α-Dihydro prednisolone
    		Control
    20α-Dihydro prednisolone is a metabolite of Prednisolone (HY-17463).
    20α-Dihydro prednisolone
  • HY-W740216
    N-Demethyl Mifepristone
    		Antagonist
    N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone.
    N-Demethyl Mifepristone
  • HY-15234R
    Fluticasone furoate (Standard)
    		Activator
    Fluticasone furoate (Standard) is the analytical standard of Fluticasone furoate. This product is intended for research and analytical applications. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.
    Fluticasone furoate (Standard)
  • HY-B0603R
    Fluticasone (Standard)
    		Agonist
    Fluticasone (Standard) is the analytical standard of Fluticasone. This product is intended for research and analytical applications. Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.
    Fluticasone (Standard)
  • HY-131543
    22-Hydroxy mifepristone
    		Inhibitor
    22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48%.
    22-Hydroxy mifepristone
  • HY-142123R
    Fluocortolone (Standard)
    Fluocortolone (Standard) is the analytical standard of Fluocortolone. This product is intended for research and analytical applications. Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg).
    Fluocortolone (Standard)
  • HY-157585S
    21-Dehydro Budesonide-d8-1
    		Agonist
    21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies.
    21-Dehydro Budesonide-d<sub>8</sub>-1
  • HY-B0214S3
    Prednisone-13C2,d2
    		Agonist
    Prednisone-13C2,d2 (Dehydrocortisone-13C2,d2) is 13C labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
    Prednisone-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-B1197R
    Amcinonide (Standard)
    		Agonist
    Amcinonide (Standard) is the analytical standard of Amcinonide. This product is intended for research and analytical applications. 0
    Amcinonide (Standard)
  • HY-U00169
    Prednisolone farnesylate
    Prednisolone farnesylate (PNF21) is a new transdermal corticosteroid with anti-inflammatory activity.
    Prednisolone farnesylate
  • HY-U00161
    Betamethasone 17-benzoate
    Betamethasone 17-benzoate is a representative steroid, which can be used in the treatment of recurrent aphothous ulcers (RAU).
    Betamethasone 17-benzoate
Cat. No. Product Name / Synonyms Application Reactivity